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. 2017 Apr 19;9(1):15–32. doi: 10.1007/s13238-017-0408-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Relationship between MABEL, NOAEL, therapeutic window and toxicity in FIH trial. MABEL: minimally anticipated biological effect level; NOAEL: no observed adverse effect level. Modified from Muller et al., Curr Opin Biotechnol. (2009)