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. 2017 Jun 8;9(1):47–62. doi: 10.1007/s13238-017-0433-3

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Comparison of sialylated and native Fc structures. (A) Superposition of enzymatically sialylated Fc (blue) (PDB ID code: 4BYH) and native Fc (gray) (PDB ID code: 1H3Y). (B) Superposition of chemoenzymatically synthesized disialylated Fc (magenta) (PDB ID code: 4Q6Y) and native Fc (gray) (PDB ID code: 3AVE). The monosaccharides fucose, GlcNAc, mannose, galactose, and sialic acid are shown in magenta, yellow, gray, green and red, respectively. The molecular models were produced with PyMOL (The PyMOL Molecular Graphics System, Version 1.8.5.0, Schrodinger, LLC)