Table 2.

An alignment of the hinge, CH2, and CH3 region for human IgG1 according to IMGT unique numbering (http://www.imgt.org/IMGTScientificChart/Numbering/Hu_IGHGnber.html) and EU numbering is shown.

Note: The core hinge region is defined by the N-terminal and C-terminal cysteines that link the two heavy chains together (Liu and May, 2012). The lower hinge region ends with the final amino acid prior to the start of the first CH2 β-sheet domain (as shown in PDBID: 3AVE, 1HZH, 5KD3, and 4HAG). The red, green, and blue coloring scheme is the same that was used in Fig. 1