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. 2018 Jan 22;8:1381. doi: 10.1038/s41598-018-19794-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,b) Examples of α-Calretinin immunostaining in the hippocampus proper and dentate gyrus of adult Sema3E^+/+ and Sema3E^+/0 (a) and Sema3E^0/0 (b) mice. Note the presence of several waves in the IML of the suprapyramidal blade (arrows in b). (c–f) Photomicrographs illustrating the pattern of selenite-silver staining (TIMM) in Sema3E^+/0 and Sema3E^+/+ (c,e) and Sema3E^0/0 (d,f) mice. Note the numerous ectopic mossy fibers crossing the granule cell layer entering the molecular layer of mutant mice (arrows in d,f). (g–h) Double immunolabeling of Synaptoporin (SPO, green) and NeuN (red) in the dentate gyrus of Sema3E^+/+ and Sema3E^+/0 (g) and Sema3E^0/0 (h) mice showing ectopic mossy fibers crossing the granule cell layer in mutant mice (arrows in h). (i–j) High-power photomicrographs illustrating the pattern of selenite-silver staining (TIMM) in control (Nestin-cre; PlxnD1^flox/+) and PlexinD1-deficient (Nestin-cre; PlxnD1^flox/flox) mice. Abbreviations as in Figs 1–5 and CALR = calretinin; SPO = synaptoporin. Scale bar: a = 500 μm pertains to b; c = d = 500 μm. e = 150 μm pertains to (f,i–j); g = h = 100 μm.