Table 2.
Tentative role of identified proteins in apoptosis/toxicity.
| Spot No. | Name of protein | Role in apoptosis (Yes/No) | Role of identified protein in apoptosis (from earlier reports)• | References |
|---|---|---|---|---|
| 2 | Glucose-regulated protein 78 kDa | Y | Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein reported recently in case of cancer | 53 |
| 3 | Regucalcin | Y | Inhibits PPase activity; over expression suppresses apoptotic cell death | 54 |
| 4 | Serum albumin precursor | Y | Specific inhibitor of apoptosis reported in endothelial cells | 55 |
| 5 | Alpha-enolase-like isoform 2 | Y | A target of antibodies which induces cell death through an apoptotic process | 40 |
| 6 | Aldehyde dehydrogenase2, mitochondrial, isoform CRA_a | Y | Target of MCYST-LR other than PP1 & 2 A. Involved in acetaldehyde detoxification & prevention of free redical; over expression attenuate alcohol exposure induced apoptosis in liver. | 38 |
| 8 | Glutathione S-transferase Mu 1 | Y | It modulates the stress activated signal by suppressing apoptosis signal regulating kinase 1 (As K1, which play critical role in cytokine and stress induced apoptosis | 41 |
| 10 | 3-hydroxyanthranilate 3,4-dioxygenase | Y | Induces apoptosis in monocyte derived cell stimulated by interferon-gamma | 39 |
| 12 | Mouse glycine N-methyltransferase | Y | Major hepatic enzyme which regulate mediating methyl group availability in mammalian cells | 56 |
| 13 | RecName: Full = Catalase | Y | Catalase protect HepG2 cell from apoptosis induced by DNA damaging agents | 57 |
| 14 | Hemoglobin α, adult chain 2 | Y | act as strong pro-apoptotic regulator | 37 |
| 15 | RecName: Full = Fumarylacetoacetase | Y | Tyrosenimia type 1 and apoptosis caused by deficiency of fumarylacetoacetate hydrolase (FAH) activity | 58 |
| 16 | Carbonic anhydrase 2 | Y | Identified in autoimmune related pancreatitis | 59 |
•Role of six identified proteins viz: Immunoglobulin heavy chain VDJ region (1), aldolase 2, B isoform, isoform CRA_b (7), alpha-dystrobrevin 2a (9), keratin, type II cytoskeletal 2 epidermal (11), immunoglobulin heavy chain VDJ region (17), and mCG142516, isoform CRA_b (18) in apoptosis is not available in database.