Table 2.
MiRNAs up-regulated in maternal GDM in whole blood cells collected during pregnancy (sorted by fold-changes).
| Name | FC | logCPM | P | FDR |
|---|---|---|---|---|
| miRNA-199a-3p | 2.213 | 3.917 | 7.50E-03 | 0.083 |
| miRNA-199b-3p | 2.213 | 3.917 | 7.50E-03 | 0.083 |
| miRNA-15a-5p | 2.169 | 9.190 | 4.88E-03 | 0.072 |
| miRNA-19a-3p | 2.154 | 5.782 | 1.48E-03 | 0.035 |
| miRNA-96-5p | 2.036 | 7.029 | 1.65E-04 | 0.020 |
| let-7g-5p | 1.965 | 12.247 | 4.32E-04 | 0.024 |
| miRNA-143-3p | 1.946 | 7.242 | 8.72E-04 | 0.028 |
| miRNA-340-5p | 1.907 | 6.828 | 7.06E-04 | 0.028 |
| miRNA-142-5p | 1.882 | 11.583 | 3.36E-04 | 0.024 |
| miRNA-1307-5p | 1.870 | 5.413 | 1.04E-03 | 0.028 |
| let-7f-5p | 1.836 | 11.930 | 5.32E-03 | 0.072 |
| miRNA-107 | 1.825 | 9.919 | 6.44E-04 | 0.028 |
| let-7c-5p | 1.749 | 4.566 | 1.81E-04 | 0.020 |
| miRNA-18a-5p | 1.735 | 4.410 | 8.56E-03 | 0.088 |
| miRNA-660-5p | 1.730 | 6.842 | 2.15E-03 | 0.041 |
| miRNA-17-3p | 1.728 | 5.856 | 2.15E-04 | 0.020 |
| miRNA-19b-3p | 1.629 | 9.256 | 5.28E-03 | 0.072 |
| miRNA-106b-5p | 1.617 | 8.228 | 5.65E-03 | 0.073 |
| let-7a-5p | 1.611 | 12.127 | 1.10E-03 | 0.028 |
| miRNA-451a | 1.606 | 17.754 | 3.96E-03 | 0.067 |
| let-7e-5p | 1.589 | 3.544 | 8.35E-03 | 0.088 |
| let-7i-5p | 1.589 | 11.408 | 6.85E-03 | 0.082 |
| miRNA-148a-3p | 1.584 | 11.695 | 4.21E-03 | 0.067 |
| miRNA-22-3p | 1.577 | 13.539 | 9.01E-04 | 0.028 |
| miRNA-17-5p | 1.571 | 9.101 | 9.47E-03 | 0.094 |
| miRNA-145-5p | 1.569 | 4.349 | 6.23E-03 | 0.078 |
| miRNA-93-5p | 1.546 | 10.233 | 3.88E-03 | 0.067 |
| miRNA-103a-3p | 1.495 | 12.179 | 1.75E-03 | 0.035 |
| miRNA-103b | 1.495 | 12.179 | 1.75E-03 | 0.035 |
Table 2 lists miRNAs significantly (P < 0.05; FDR < 0.1) associated with GDM in the screening group. The samples were paired based on maternal age and BMI and adjusted for maternal weight gain and pregnancy week. GDM was defined as endpoint variable. Fold-changes (FCs) are shown in the 2nd and logarithmically transformed counts per million (logCPM), indicating the relative abundance of the transcript. are shown in the 3rd column of the table. Uncorrected P-values and false discovery rates (FDRs) are indicated in the 4th and 5th column, respectively. MiRNAs shown in bold fonts indicate those which were selected for q-PCR validation experiments.