Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 22;8:1329. doi: 10.1038/s41598-018-19577-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Longitudinal ADAM10 mRNA measurement in untreated healthy controls and in alcohol addicted patients treated with disulfiram. (a) Two groups of subjects were included in the investigation: healthy controls and alcohol dependent subjects. Both groups were matched for age and smokers rate. The gender rate differs significantly between the groups but represents normal ratios found in the healthy as well as the alcohol dependent part of the population (28). The alcohol dependent subjects were treated with disulfiram following the normal treatment schedule of the clinical centres (Department of Psychiatry and Psychotherapy, Mainz or CIMH, Mannheim). From both groups blood was sampled by venipuncture on day 1 and approx. 17 days later. One patient was excluded from the investigation due to lack of compliance and extremely extended time point for the second blood draw (3 months). (b) ADAM10 mRNA level was quantified from total RNA preparations in healthy controls and alcoholic dependent patients treated with disulfiram and is presented as the ratio between values obtained after ca. two weeks and at baseline (RNA amount was normalized to PGK-1 RNA levels). Mean and SEM are indicated. Statistical analysis: unpaired Student’s t-test (*p < 0.05).