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. 2018 Jan 22;8:1357. doi: 10.1038/s41598-018-19744-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aminode example: Analysis of transcription factor EB (TFEB). Upper panel, Aminode graphical output. The red line represents the relative rate of amino acid substitution calculated at each protein position. Local minima (highlighted by yellow bars above the graph) are constrained regions with relatively low substitution rates. Peaks (local maxima) indicate regions with relatively high substitution rates. The amino acid sequences for each ortholog are shown in shades of blue to green (more conserved to less conserved) in the background of the graph. Lower panel, Schematic of TFEB protein structure showing the position of the DNA-binding bHLH domain, the leucine zipper domain (L) and various known sites of post-translational modification that regulate TFEB function (references in the text).