Table 2.
Clinical Characteristics and Exposition to Risk Factors for IA-Affected Case Subjects and Unaffected Relatives, According to ANGPTL6 Status
| Healthy Individuals; No ANGPTL6 Variant (n = 16a) | Healthy Individuals; ANGPTL6 Variant (n = 15) | IA Carriers; ANGPTL6 Variant (n = 12) | |
|---|---|---|---|
| Median age | 57 | 56 | 59 |
| Female sex | 56% | 53% | 58% |
| History of smoking | 56% (8 p.y.b) | 73% (10 p.y.b) | 67% (31 p.y.b) |
| High blood pressure | 7% | 9%c | 50%c |
| Alcohol intake > 150 g/w | 19% | 13% | 33% |
| Median BMI | 22 | 24 | 24 |
| Diabetes - dyslipidemia | 19% | 18% | 33% |
a
Healthy individuals aged over 35 years, without ANGPTL6 variant
b
p.y., median consumption in pack/years among smokers
c
Significant difference between affected versus healthy individuals carrying ANGPTL6 variants; p = 0.013 (chi-square test)