Fig. 5.

Pharmacokinetics and pharmacokinetic–pharmacodynamic relationship. a Plasma was collected at indicated intervals for assay of atovaquone concentrations in mice dosed intramuscularly with 200 mg kg^{−1 ATQ}SDN₇. Log-transformed concentrations yield a plasma half-life of 105 h (using 4–42 days values, inclusive; R², 0.985); data obtained in six independent experiments. Insert, At 14 days after intramuscular injection, plasma concentrations (y-axis, ng mL⁻¹) were linear with dose (x-axis, mg kg⁻¹). b Plasma atovaquone concentrations > 200 ng mL⁻¹ at the time of challenge correlate well with efficacy. Each dot represents a cohort of 3–5 mice, 7–42 days after a single intramuscular dose of 36, 50, 100 or 200 mg kg^{−1 ATQ}SDN₇. Data from six independent experiments