Fig. 4.

Orai1 inhibitors 2-APB, MRS-1845, and YM-58483 inhibit Ca²⁺-responsive implantation genes. Arithmetic means ± SEM (n = 6) of BMP2, WNT4, and COX2 transcript levels relative to that of L19 (housekeeping) in primary HESC cultures that were treated with 8-Br-cAMP and MPA for 6 days in the absence (dotted line) or in presence of the Orai-1 inhibitors 2-APB (50 μM), MRS-1845 (10 μM), or YM-58483 (10 μM); **P < 0.01 indicates significant difference from the control using Student’s t test