Table 2.

Multivariate analyses and the ORs for extensive white matter lesions (extWML) detected on MRI (n=1714)

Variable	β	OR	95% CI lower	P value
Intercept	−3.0047	–	–	<0.0001
Diastolic BP (per 1 mm Hg increase)	0.0156	1.016	1.006 to 1.026	0.0018
Psychotropic drug use	0.3660	1.442	1.113 to 1.868	0.0056
Antihypertensive drug use	0.5545	1.741	1.388 to 2.185	<0.0001
Dependence in at least one IADL	0.6427	1.902	1.140 to 3.171	0.0138
Forgetfulness	0.2455	1.278	1.017 to 1.607	0.0354
Difficulties with simple arithmetic calculations	0.3942	1.483	1.108 to 1.986	0.0081

The classification of extWML was based on upper quartile stratified by sex as; >6.03 cm³ for men and 4.91 cm³ for women. The regression model used a backward stepwise deletion procedure for covariates using a threshold for inclusion of P<0.05.

BP, blood pressure; IADL, instrumental activities of daily living.