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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Annu Rev Vis Sci. 2017 Jul 17;3:25–51. doi: 10.1146/annurev-vision-102016-061338

Figure 2. A model for TRPM1 channel gating by G proteins.

Figure 2

Direct binding of both activated Gαo-GTP and Gβγ subunits to the cytoplasmic domains of the TRPM1 channel keep it in closed state. Upon GTP hydrolysis, G proteins rearrange forming inactive heterotrimer allowing the TRPM1 channel to open. Modified from (Xu et al. 2016).