TABLE 1.
Clinical measures by speciesa
| Clinical measure | % of macaques (n) |
||
|---|---|---|---|
| CCM (n = 26) | Rhesus (n = 18) | MCM (n = 6) | |
| Coughingb | 19.2 (5) | 66.7 (12) | 33.3 (2) |
| ESR of ≥5 mm/h | 53.9 (14) | 61.1 (11) | 16.7 (1) |
| CFU+ GA or BAL (>60 days p.i.) | 46.2 (12) | 72.2 (13) | 33.3 (2) |
| Humane euthanasia endpointc | 15.4 (4) | 38.9 (7) | 66.7 (4) |
a
Cough, erythrocyte sedimentation rate (ESR) of at least 5 mm/h at any time postinfection, and M. tuberculosis growth (CFU represents colony-forming units) from gastric aspirate (GA) samples or bronchoalveolar lavage (BAL) fluid samples after 60 days postinfection were recorded for each animal in the study, and percentage of positive macaques for each species is shown. The percentages of each species that had early necropsies (humane euthanasia endpoint) due to clinical concerns are displayed here. The Fisher exact test was used to compare CCM and rhesus macaques only.
b
P < 0.01.
c
P = 0.0926.