Variable	Criteria	Score
Family history	First-degree relative with premature CAD*, or first degree relative with LDL-C > 95th centile	1
	First-degree relative with tendon xanthomata and/or corneal arcus, or children < 18 years with LDL-C > 95th centile	2
Clinical history	Premature CAD*	2
	Premature cerebral or peripheral vascular disease*	1
Physical examination	Tendon xanthomata	6
	Corneal arcus < 45 years	4
LDL-C	> 8.5 mmol/l (> 325 mg/dl)	8
	6.5–8.4 mmol/l (251–325 mg/dl)	5
	5.0–6.4 mmol/l (191–250 mg/dl)	3
	4.0–4.9 mmol/l (155–190 mg/dl)	1
DNA analysis	Functional mutation in LDLR, apoB or PCSK9 gene	8
Definite FH	Score > 8
Probable FH	Score 6–8
Possible FH	Score 3–5
No diagnosis	Score < 3

*Male < 55 years, female < 60 years. CAD – coronary artery disease, LDL-C – low density lipoprotein cholesterol.