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. 2017 Dec 4;46(2):558–567. doi: 10.1093/nar/gkx1220

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Graphical representation of the two-state model. The two continuous curves represent the energy levels of the two modes of a TF, equal to E^α(x) (recognition mode, top curve) and (search mode, bottom curve). The dashed lines denote the average energy in the two modes. The arrows represent the transitions in the stochastic model, characterized by the rates in Equation (3).

Inline graphic — Graphical representation of the two-state model. The two continuous curves represent the energy levels of the two modes of a TF, equal to E^α(x) (recognition mode, top curve) and (search mode, bottom curve). The dashed lines denote the average energy in the two modes. The arrows represent the transitions in the stochastic model, characterized by the rates in Equation (3).