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. 2017 Dec 4;46(2):558–567. doi: 10.1093/nar/gkx1220

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — AT frequency bias b(r) (5) as a function of distance r from the target. The curve labeled TFBS at actual position displays b(r) computed over the whole set of 1544 unique target sequences in the DB (see ‘Materials and Methods’ section). The other curve represents the same quantity computed with TFBS at randomized positions (as labeled) on the DNA. The randomized computation is performed as in Figure 2. Inset: comparison between and b(r), as in the legend, in linear-log scale. The white thick lines are an exponential fit aexp ( − |r|/ℓ_f), yielding ℓ_f ≈ 120 bp and a ≈ 0.128.

Inline graphic — AT frequency bias b(r) (5) as a function of distance r from the target. The curve labeled TFBS at actual position displays b(r) computed over the whole set of 1544 unique target sequences in the DB (see ‘Materials and Methods’ section). The other curve represents the same quantity computed with TFBS at randomized positions (as labeled) on the DNA. The randomized computation is performed as in Figure 2. Inset: comparison between and b(r), as in the legend, in linear-log scale. The white thick lines are an exponential fit aexp ( − |r|/ℓ_f), yielding ℓ_f ≈ 120 bp and a ≈ 0.128.