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TDP1 substrates. (A) 3′-phosphotyrosyl peptide - canonical substrate of TDP1. (B) 3′-phosphoamide adducts formed by H493R-mutant TDP1 causing covalent linkage of H263-TDP1 to 3′-DNA end. (C) 3′-phosphoglycolates. (D) 3′-deoxyribose phosphate and (E) 3′-abasic sites produced because of oxidative DNA damage. (F) 5′-phosphotyrosyl peptide. (G–J) Chain terminating nucleoside analogs.
