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TDP2 substrates. (A) 5′-phosphotyrosyl–DNA—canonical substrate of TDP2. (B) 3′-phosphotyrosyl–DNA. (C) 5′-phosphotyrosyl-RNA, 5′-VPg from picornaviridae family of viruses, 5′-P-protein from Hepatitis B virus. (D) p-Nitrophenyl-thymidine-5′-phosphate (T5PNP) is processed by TDP2 producing thymidine-5′-monophosphate and p-nitrophenol, which can be used in a simple colorimetric TDP2 activity assay.
