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. 2017 Dec 14;46(2):730–747. doi: 10.1093/nar/gkx1240

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — PABPN1 is physically recruited to sites of DNA damage. Live imaging snapshots demonstrate the accumulation of ectopic GFP-PABPN1 in WT (A) or S95A (B) form in areas of laser-induced DNA damage in U2-OS cells. Note the kinetics of PABPN1 recruitment to DNA damage sites (lower panel of A). (C) Lack of effect on PABPN1 recruitment of the ATM inhibitor, KU55993 applied at 10 μM 30 min prior to irradiation. Recruitment of GFP-tagged polynucleotide kinase-phosphatase (GFP-PNKP) (63,119) served as control for induction of DNA damage.