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. 2017 Dec;7(Suppl 3):S140–S149. doi: 10.21037/cdt.2017.08.01

Figure 5.

Figure 5

Immunohistochemistry of NETs in cirrhosis and hepatocellular carcinoma (HCC) liver tissue. Red = anti-histone H2A/H2B/DNA complexes (NETs); blue = nuclear counterstaining (DAPI). (A) There are extensive NETs immunostaining in areas corresponding to HCC (arrows) compared to the adjacent non-cancer, cirrhosis segments that show only nuclear immunostaining. (B) Higher magnification of HCC segments demonstrates the extensive extracellular NETs immunostaining (arrows). (C) Higher magnification of a cirrhosis segment demonstrating minimal extracellular NETs signal (arrow); white bar indicates 200 microns in (A) and 100 microns in (B,C). DAPI, 4',6-diamidino-2-phenylindole. NETs, neutrophil extracellular traps.