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. 2017 Dec;7(Suppl 3):S140–S149. doi: 10.21037/cdt.2017.08.01

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2017 Cardiovascular Diagnosis and Therapy. All rights reserved.

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Immunohistochemistry of NETs in small-cell lung cancer. Red = anti-histone H2A/H2B/DNA complexes (NETs); blue = nuclear counterstaining (DAPI). (A) There are intense extracellular NETs signal detected within foci of cancer tissue (arrow) compared to adjacent segments (arrow head). (B) Higher magnification views reveal detection of intense lace-like extracellular network of NETs (arrow) compared to adjacent tissue (arrowhead); white bar indicates 500 microns in (A) and 100 microns in (B).