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. 2017 Dec 9;46(2):546–557. doi: 10.1093/nar/gkx1241

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Binding isotherm obtained from ITC show the specific binding interactions of AP-1 cognate DNA with veratramine (compound 1529, upper three subfigures) and compound 1125 (lower three subfigures). (A) The chemical structures of veratramine and compound 1125. (B) ITC data for the titration of veratramine (upper panels) and compound 1125 (lower panels) into three types of DNA sequences (from left to right, AP-1 cognate DNA; AP-1 mutant DNA; and randomly-designed DNA). The upper portion in each panel shows the change in enthalpy per injection of veratramine (compound 1529) or 1125 into a corresponding DNA sequence. The lower portions indicate the concentration normalized heat form titration at the molar ratio of compounds.