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. 2018 Jan 22;19:15. doi: 10.1186/s12931-017-0701-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Bronchoalveolar lavage (BAL) total (a) and differential cell counts (b, c) for wildtype (WT) and mice not expressing TLR4 (TLR4−/−) for each treatment. Elevated total cell counts in BAL were observed in WT mice treated with AMP, LPS and AMP-LPS compared to WT control mice. Cell counts in WT mice treated with LPS and AMP-LPS were also greater than similarly treated TLR4−/− mice. Neutrophils were the predominant cell type in LPS and AMP-LPS treated WT mice. Macrophages dominated counts in AMP treated WT and TLR4−/− mice, as well as LPS and AMP-LPS treated TLR4−/− mice compared to respective controls. Greater eosinophil numbers were observed in WT mice treated with LPS and AMP-LPS; for which numbers were greater in AMP-LPS treated mice. Lymphocyte and epithelial cell numbers were not significantly different between controls and any of the treatments given for either strain (*p < 0.05 between treatment and control; # = p < 0.05 between strains for the same treatment; α = p < 0.05 between treatment compared to all other treatments for the same strain)