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. 2018 Jan 22;19:69. doi: 10.1186/s12864-018-4450-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Circos plot of genome-wide DNA methylation changes between migraine cases and non-migraine controls. The inner circle displays an ideogram ordered by chromosome number; black dots represent combined P values using Fisher’s method for each 1-kb sliding region (dots pointing outwards represent hypermethylated windows while the dots pointing inwards represent hypothmetylated regions); green and red dots represent significant (FDR < 0.05) hypermethylated and hypomethylated regions, respecitvely. The middle circle shows the baseline beta-value difference between migraine cases and non-migraine controls for genome-wide signficant regions; the green lines represent hypermethylated regions and red lines hypomethylated regions, and the length of each line represents the beta-value difference. The outermost circles display the RefSeq genes associated with hypomethylated (red) and hypermethylated regions (green)