Table 2.

Ten most significant differentially methylated regions associated with migraine

Chromosome	Start (bp)	End (bp)	Direction	P value	FDR	No. of Probes	RefSeq gene(s)
11	20,625,538	20,628,781	Decrease	2.54 × 10− 17	4.16 × 10− 12	10	SLC6A5
6	30,033,321	30,046,936	Decrease	1.50 × 10− 14	1.23 × 10− 9	128	PPP1R11, RNF39
9	124,987,896	124,992,432	Increase	1.65 × 10− 12	8.99 × 10−8	13	LHX6
3	185,911,208	185,913,486	Decrease	5.28 × 10−12	2.16 × 10−7	9	DGKG
13	31,506,270	31,508,139	Decrease	2.15 × 10−11	7.04 × 10−7	11	TEX26, TEX26-AS1
11	67,417,958	67,419,405	Decrease	6.54 × 10−10	1.79 × 10− 5	13	ACY3
5	156,886,147	156,888,490	Decrease	1.26 × 10−9	2.95 × 10− 5	12	LOC102724404, NIPAL4
6	74,070,966	74,075,136	Increase	1.99 × 10−9	4.08 × 10− 5	16	KHDC3L
12	52,403,511	52,405,422	Decrease	2.65 × 10−9	4.34 × 10− 5	6	GRASP
13	31,479,366	31,482,184	Decrease	2.46 × 10−9	4.34 × 10−5	13	MEDAG, TEX26-AS1