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Acute toxic effects (n = 112)
| Toxic effect | All grades | Grade 3 and 4 | ||
|---|---|---|---|---|
| Single-agent(n = 76) | Two-agent (n = 36) | Single-agent(n = 76) | Two-agent (n = 36) | |
| No (%) | No (%) | No (%) | No (%) | |
| Neutropenia | 49(64.5) | 30(83.3) | 26(34.2) | 19(52.7%) |
| Thrombocytopenia | 12(15.8) | 9(25.0) | 5(6.6) | 4(11.1) |
| Anemia | 36(47.4) | 25(69.4) | 1(1.3) | 2(5.6) |
| Nausea/vomiting | 14(18.4) | 11(30.1) | 1(1.3) | 1(2.8) |
| Esophagitis | 51(67.1) | 28(77.8) | 6(7.9) | 3(8.3) |
| Pneumonitis | 7(9.2) | 5(13.9) | 0(0) | 0(0) |
| Liver function | 15(19.7) | 10(27.8) | 0(0) | 1(2.8) |
