Fig. 3.

RAGE neutralizing antibody prevents AGE-induced neuronal death. a. Representative images show 0.1 μg/μl BSA or AGE-treated G2019S LRRK2 neurons. RAGE neutralizing antiserum pretreated for 30 min. After 24 h, neurons (15DIV) were immunostained with MAP2 (red) antibody. Scale bar, 20 μm. b. Bar graph shows quantification of survived cells in (a). Data are presented as mean ± SD for three independent experiments. ^***P < 0.001 compared with BSA-treated cells. ^##P < 0.01 compared with AGE-treated cells