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. 2017 Dec 20;15(3):3369–3375. doi: 10.3892/ol.2017.7669

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Figure 5. — CCAT2 is involved in Wnt/β-catenin signaling pathway. (A) TOP-FLASH luciferase reporter assay showed that knockdown of CCAT2 downregulated TCF/LEF activity in SKOV3 and A2780. (B) The expression of CCAT2 was increased by LiCl treatment (20 mM, for 24 h) to further activate canonical Wnt/β-catenin signaling. (C) Knockdown of CCAT2 decreased the expression of β-catenin both in the nucleus and cytoplasm at the protein level in SKOV3 and (D) A2780 cells. The data represent the mean ± SD of three independent experiments. The values of the controls were set as 1. *P<0.05 compared to NC group; ^#P<0.05 compared to SI+NaCl group (Student's t-test). CCAT2, colon cancer-associated transcript 2; NC, negative control; siRNA, small interfering RNA; LiCl, lithium chloride; TOP-FLASH, TCL/LEF-Firefly luciferase; LiCl, lithium chloride.