Table I.
Mutations or gene fragments detected by ARMS-Plus.
| Site | Mutation | Exon | Base pair altered | Cosmic ID |
|---|---|---|---|---|
| EGFR external control | / | 4 | / | / |
| Del(1) | E746_A750del(1) | 19 | 2235_2249del15 | 6223 |
| Del(2) | E746_A750del(2) | 19 | 2236_2250del15 | 6225 |
| L858R | L858R | 21 | 2573T>G | 6224 |
| T790M(1) | T790M | 20 | 2369C>T | 6240 |
| T790M(2) | T790M | 20 | 2361G>A/2369C>T | 1451600/6240 |
The mutant abundance of 19Del mutation is the sum of Del(1) and Del(2), while the one with a larger value between T790M(1) and T790M(2) was chosen as the T790M mutant abundance. COSMIC, catalogue of somatic mutations in cancer; EGFR, epidermal growth factor receptor; 19Del, exon 19 deletion; ARMS, amplification refractory mutation system.