Figure 1.

Illustrations of ABPs in the nucleus. ABPs are involved in chromatin remodeling, gene transcriptional regulation, DNA damage repair, nucleocytoplasmic transport and nuclear structure maintenance. ABP, actin-binding protein; INM, inner nuclear membrane; ONM, outer nuclear membrane; NPC, nuclear pore complex; LINC, linker of nucleoskeleton and cytoskeleton complex; SUN, SUN domain proteins; KASH, KASH domain; FLII, flightless I homolog; SWI/SNF, SWItch/Sucrose Non-Fermentable chromatin remodeling complex; ACTN 4, α-actinin 4; ERα, estrogen receptor α; TF, transcription factor; FLNα, filamin α; NF-κB, nuclear factor κ-light-chain enhancer of activated B-cells; BRCA2, breast cancer type 2; BRCA1, breast cancer type 1.