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. 2017 Dec 19;15(3):2735–2742. doi: 10.3892/ol.2017.7638

Figure 1.

Figure 1.

Interaction of miRNAs as oncogenic and tumor suppressor. let-7 suppresses translation of the Ras GTPase genes. The downregulation of let-7 promotes the cell cycle through the Ras-MAPK pathway. miR-17-92 may prohibit oncogene-induced apoptosis. PTEN, phosphatase and tensin homolog; PI3K, phosphoinositide-3 kinase; PKB, protein kinase B; MAPK, mitogen-activated protein kinase; ARF, alternative reading frame protein of p16INK4a locus. miRNA/miR, microRNA; p53, tumor protein 53; E2F1, transcription factor E2F1; Akt, RAC-α serine/threonine-protein kinase.