Table III.
Comparison of clinicopathological factors between Wnt3a-positive and Wnt3a-negative groups in pathological stage III ESCC.
| Parameters | Total (n=57) | Wnt3a-positive (n=32) | Wnt3a-negative (n=25) | P-value |
|---|---|---|---|---|
| Age (years; mean) | 64.3 | 66.1 | 61.9 | 0.063 |
| Sex | 0.520 | |||
| Male | 45 | 24 | 21 | |
| Female | 12 | 8 | 4 | |
| Location of tumor | 0.972 | |||
| Upper | 5 | 3 | 2 | |
| Middle | 30 | 17 | 13 | |
| Lower | 22 | 12 | 10 | |
| Size of tumor (mean) | 55.5 | 58.1 | 52.2 | 0.292 |
| Serum SCC level (ng/ml; mean) | 0.225 | |||
| 15 | 6 | 9 | ||
| 42 | 26 | 16 | ||
| Differentiation | 0.265 | |||
| Well | 18 | 8 | 10 | |
| Moderate | 19 | 10 | 9 | |
| Poorly | 20 | 14 | 6 | |
| Lymphatic invasion | 1.000 | |||
| Positive | 55 | 31 | 24 | |
| Negative | 2 | 1 | 1 | |
| Venous invasion | 0.309 | |||
| Positive | 53 | 31 | 22 | |
| Negative | 4 | 1 | 3 | |
| INF | 0.589 | |||
| a | 1 | 1 | 0 | |
| b | 43 | 23 | 20 | |
| c | 13 | 8 | 5 | |
| Adjuvant chemotherapy | 0.141 | |||
| + | 42 | 21 | 21 | |
| − | 15 | 11 | 4 |
ESCC, esophageal squamous cell carcinoma; SCC, squamous cell carcinoma; INF, infiltrative growth pattern.