Extended Data Figure 3. Comparison of K_2P modulator and VGIC antagonist sites.

a, Superposition of the K_2P2.1(TREK-1):ML335 complex (smudge and light orange) with the BacNa_V ‘pore-only’ Na_VMs structure¹⁸ (magenta and warm pink). Bromine site (Br) from labeled sodium channel antagonists is shown as a firebrick sphere. b, Superposition of the pore domains of the K_2P2.1(TREK-1):ML335 complex (smudge and light orange) with the pore domain of the BacNa_V Ca_VAb (5KMD) bound to the inhibitor amlodipine (AMLOD)¹⁹, a site normally occupied by lipid^19,37. Select residues of the K_2P modulator pocket are shown as sticks and are labeled. Ca_VAb subunits are colored cyan, marine, slate, and dark blue. ML335 (yellow) and amlodipine (cyan) are shown in space filling representation.