Table V.
Potential target genes for miRNAs differentially expressed in response to the soft-shelled turtle peptides.
| miRNA | Target gene | Function of the encoded protein |
|---|---|---|
| hsa-miR-429 | CERS6 | Sphingolipid biosynthesis |
| MIB1 | Ubiquitination | |
| CBL | Regulation of tyrosine kinases | |
| HOOK1 | Early endosome trafficking | |
| ZNF148 | Regulation of cell growth, apoptosis | |
| hsa-miR-454 | SUN2 | Interaction with chromatin and the nuclear lamina |
| ADAM28 | Sperm maturation and immune suppression | |
| KDM2A | Cell proliferation, differentiation of mesenchymal stem cells derived from dental tissue | |
| hsa-miR-98 | COL4A2 | Assembled with COL4A1, interaction with growth factors and cell surface receptors |
| MAP4K3 | Cell growth, viability, cell death, body size and metabolism | |
| IL13 | Mediator of allergic inflammation | |
| IGF2BP1 | Embryo development, oncofetal RNA-binding protein | |
| hsa-miR-7 | S100A7A | Inflammation, tumorigenesis |
| EGFR | Cell growth, proliferation, differentiation | |
| SUCNR1 | Paired with succinate, cell metabolism | |
| ZEB2 | A key regulator of epithelial mesenchymal differentiation | |
| PIK3AP1 | Regulation of cell proliferation, survival, metabolism, cytoskeletal reorganization and membrane trafficking | |
| CD86 | Immune responses | |
| ADAM9 | Upregulation associated with tumorigenesis | |
| hsa-miR-502-5p | KIF1B | Axonal transport of synaptic vesicles and mitochondria, axon myelination and outgrowth |
| RNF14 | Mitochondrial transcription, immune function | |
| GRAP2 | Calcium influx and cytokine production | |
| hsa-miR-378h | CBL | Regulation of tyrosine kinases |
| PTCH1 | A key regulator of cell proliferation, cell surveillance, embryonic development, adult tissue homeostasis and stem cell quiescence | |
| SULF1 | Blocking the binding of growth factors and receptors, regulation of cell growth and differentiation | |
| TRAF3 | Regulation of signaling through B-lymphocyte receptors, inhibition of B-cell homoeostatic survival | |
| CELF2 | Regulation of mRNA editing, stability and translation | |
| hsa-miR-665 | SRF | A transcription factor for coupling actin dynamics and signaling pathways to gene expression |
| SMAD7 | An antagonist of TGF-β signaling | |
| BCL7B | Negatively regulating the Wnt-signaling pathway and positively regulating the apoptotic pathway | |
| ELK1 | Regulation of proto-oncogene c-fos | |
| FGF9 | Epithelial-mesenchymal interaction | |
| hsa-miR-4417 | PCDH17 | Functioning as a tumor suppressor |
| FOXO1 | Stopping cell cycle progression, promotes apoptosis, and negatively regulating angiogenesis | |
| IGFBP5 | Inducing extracellular matrix production and deposition | |
| SH2B3 | A negative regulator of multiple cytokine signaling pathways | |
| RAB6A | Regulating intracellular vesicle transport |
miR/miRNA, microRNA.