Table 1. Characteristics of the Study Population.
N=269.
| Clinical Characteristics | Without pathological diagnosis of PD n=250 (Median [IQR] or Number [%]) | With pathological diagnosis of PD n=19 (Median [IQR] or Number [%]) | P-value |
|---|---|---|---|
| Sleep Fragmentation (kRA) | 0.026 [0.022, 0.031] | 0.03 [0.02,0.04] | 0.01 |
| Age at Death (Years) | 91 [86.8,94.7] | 91 [88.6, 93.6] | 0.81 |
| Female Sex | 182 [73%] | 12 [63%] | 0.52 |
| Education (Years) | 15 [12,16] | 15 [14, 16] | 0.32 |
| Circadian Rhythmicity (Interdaily Stability) | 0.50 [0.37, 0.60] | 0.43 [0.33, 0.55] | 0.26 |
| Total Daily Activity (Counts) | 123732[68320, 207644] | 100417 [67218, 141604] | 0.14 |
| Hours of Rest per Day | 16.7 [14.7,18.6] | 17.5 [15.9, 18.4] | 0.32 |
| Reported Sleep Hours per Day | 8.0 [7.0, 8.0] | 8.0 [7.0, 9.0] | 0.28 |
| Number of Sleep Complaints | 1.0 [0.0, 2.0] | 1.0 [0.0, 1.0] | 0.49 |
| Use of Sleep Medications | 24 [9.6%] | 2 [10%] | >0.99 |
| Number of Depressive Symptoms | 1.0 [0.0, 2.25] | 1.0 [0.0, 2.25] | 0.56 |
| Severity of Neuroticism | 14.0 [12.0, 18.0] | 17.0 [12.5, 20.0] | 0.09 |
| Vascular Disease Risk | 1.0 [1.0, 2.0] | 1.0 [0.5, 1.0] | 0.25 |
| Thyroid Disease | 65 [26%] | 6 [32%] | 0.74 |
| Urinary Incontinence | 122 [49%] | 8 [42%] | 0.75 |
| BMI | 25.0 [22.2, 28.1] | 24.4 [22.0, 27.1] | 0.69 |
| Composite Global Cognition | -0.41 [-1.16, 0.12] | -1.20 [-1.64, -0.28] | 0.10 |
| Severity of Parkinsonism at Last Examination | 13.2 [7.6, 19.4] | 16.8 [13.2, 23.0] | 0.08 |
| Severity of Lewy Body Pathology at Death | <0.01 | ||
| None | 207 [83%] | 0 [0%] | |
| Subcortical | 20 [8%] | 6 [32%] | |
| Cortical | 33 [9%] | 13 [68%] | |
| Substantia Nigra Cell Loss at Death | <0.01 | ||
| None | 144 [58%] | 0 [0%] | |
| Mild | 100 [40%] | 0 [0%] | |
| Moderate to Severe | 6 [2%] | 19 [100%] | |
| Time Lag Between Actigraphy and Death (Days) | 517 [248,968] | 525 [266.5, 972.5] | 0.85 |