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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Biotechnol Bioeng. 2016 Mar 8;113(9):2020–2032. doi: 10.1002/bit.25950

Figure 1.

Figure 1

The 2-construct “metastasis-on-a-chip” device and fluidic platform for mimicking colon carcinoma metastasis from the gut to the liver. A: Photopolymerization of cells in a polymer solution forms 3-D tissue constructs. B: Device fabrication using molded PDMS pieces, inlet and outlet valves, and plastic clamps. Construct placement (“Orgs.”) is indicated by the blue and yellow zones. C: Photo and depiction of the device, and gut and liver constructs in the device under flow with migrating cancer cells. Blue arrows—direction of tissue culture media flow; Red arrows—direction of potential migration of tumor cells between constructs. D: The MOC device inline with media reservior, bubble trap, and micro-peristaltic pump, providing circulatory flow in the gut-to-liver direction.