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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Biotechnol Bioeng. 2016 Mar 8;113(9):2020–2032. doi: 10.1002/bit.25950

Figure 7.

Figure 7

Performing drug testing in the metastasis-on-a-chip device. A–B: The effects of Marimastat on HCT-116 migration. A: Marimastat prevents outward growth of aggregates from HCT-116 tumor constructs in 3-D, while control conditions do not. B: Migration of HCT-116 cells quantified by length in pixel counts. Significance: *P < 0.05 between experimental groups at each time point. C: HCT-116 tumor constructs respond in a dose dependent manner to 5-Fluorouracil (5-FU). MTS assays quantified the effects of 48-h 0, 1, 10, and 100 mM 5-Fluorouracil treatments on the mitochondrial metabolism of the HCT-116 tumor constructs. Significance: #P < 0.05 between the indicated groups.