Effects of combination simvastatin with meclofenamic acid on PC-3 cells. (A) PC-3 cells were incubated with medium containing 10% FBS. After 48 h, the PC-3 cells were cultured with or without simvastatin (5 µM) and meclofenamic acid (50 µM) in medium containing 10% FBS. After 48 h, the number of viable cells was evaluated by the MTS assay. Values are expressed as the mean ± SD (n=4). *P<0.01. (B and C) PC-3 cells were incubated with medium containing 10% FBS. After 48 h, cells were wounded and cultured with or without simvastatin (5 µM) and meclofenamic acid (50 µM). After 48 h, cell migration into the wound was examined by phase-contrast microscopy. Values are expressed as the mean ± SD (n=3). *P<0.01. sim, simvastatin.