Table V.

Univariate and multivariable Cox regression analyses for OS and DFS in 54 patients with metastatic colorectal cancer.

	Univariate (OS)			Multivariate (OS)			Univariate (DFS)			Multivariate (DFS)
Variables	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
NLR (<2.06/≥2.06)	2.012	0.859–4.712	0.107				2.158	0.980–4.752	0.056
RDW (<13.45/≥13.45)	2.628	1.170–5.901	0.019	2.755	1.194–6.361	0.018	2.742	1.313–5.724	0.007	2.684	1.258–5.725	0.011
Sex (male/female)	1.419	0.629–3.199	0.399				1.606	0.771–3.346	0.206
Age, years (<60/≥60)	1.781	0.705–4.499	0.222				1.993	0.847–4.691	0.114
Tumor location (colon/rectum)	1.692	0.619–4.623	0.305				1.603	0.591–4.350	0.354
Tumor diameter, cm (≤4/>4)	1.383	0.180–10.644	0.755				2.811	0.629–12.573	0.176
Differentiation (well/moderate/poor)	3.187	1.357–7.481	0.008	2.933	1.239–6.947	0.014	3.017	1.397–6.514	0.005	2.605	1.193–5.686	0.016
Depth of tumor (T1/T2/T3/T4)	1.263	0.370–4.307	0.709				0.958	0.355–2.585	0.933
Lymph node metastasis (N0/N1/N2)	1.265	0.574–2.785	0.560				1.196	0.576–2.483	0.631
Distant metastasis (M0/M1)	4.065	1.365–12.111	0.012				3.472	1.281–9.415	0.014
pStage (I/II/III/IV)	4.065	1.365–12.111	0.012				3.472	1.281–9.415	0.014
CEA, ng/ml (≤5/>5)	1.578	0.950–2.621	0.078				1.600	1.020–2.509	0.041
CA19-9, U/ml (≤39/>39)	1.906	1.011–3.595	0.046	2.240	1.180–4.252	0.014	1.883	1.039–3.411	0.037	2.061	1.139–3.731	0.017

Univariate analysis was performed using the Kaplan-Meier analysis model and the log-rank test and values of P<0.05 in the univariate analysis were entered into a multivariate analysis, which was performed using the Cox proportional hazards models with the forward likelihood method. OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; NLR, neutrophil-to-lymphocyte ratio; RDW, red blood cell distribution width; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9.