Table 4.
Association Between HDP Status and Offspring Cardiac Measures
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Regression Coefficient O‐HDP | P Value | Regression Coefficient O‐HDP | P Value | Regression Coefficient O‐HDP | P Value | |
| LV structural measures | ||||||
| LV diameter, diastole, cm | 0.02 (−0.06 to 0.11) | 0.591 | −0.02 (−0.10 to 0.06) | 0.568 | −0.02 (−0.10 to 0.06) | 0.654 |
| LV diameter, systole, cm | −0.02 (−0.09 to 0.06) | 0.701 | −0.03 (−0.11 to 0.05) | 0.413 | −0.03 (−0.10 to 0.05) | 0.506 |
| LV ejection fraction, % | −0.18 (−0.84 to 0.47) | 0.581 | −0.15 (−0.81 to 0.51) | 0.651 | 0.10 (−0.76 to 0.57) | 0.777 |
| LV mass index, g/m2 | −0.48 (−2.91 to 1.94) | 0.696 | −0.83 (−3.25 to 1.59) | 0.500 | −0.81 (−3.24 to 1.62) | 0.514 |
| Relative wall thickness | 0.01 (−0.02 to 0.40) | 0.477 | 0.01 (−0.02 to 0.04) | 0.476 | 0.01 (−0.02 to 0.04) | 0.475 |
| LV area end‐systole indexed BSA, mL/m2 | 0.29 (−0.02 to 0.61) | 0.069 | 0.29 (−0.03 to 0.61) | 0.078 | 0.33 (0.01 to 0.65) | 0.044 |
| LA volume indexed BSA, mL/m2 | 1.34 (0.06 to 2.61) | 0.040 | 1.14 (−0.13 to 2.41) | 0.079 | 1.29 (0.01 to 2.57) | 0.049 |
| Transmitral Doppler | ||||||
| E wave, cm/s | 1.66 (−0.55 to 3.87) | 0.140 | 1.64 (−0.56 to 3.85) | 0.144 | 1.77 (−0.46 to 3.99) | 0.119 |
| A wave, cm/s | 2.56 (0.49 to 4.64) | 0.016 | 2.08 (0.09 to 4.07) | 0.041 | 1.55 (−0.43 to 3.54) | 0.125 |
| E/A ratio | −0.05 (−0.13 to 0.02) | 0.137 | 0.04 (−0.11 to 0.03) | 0.267 | −0.02 (−0.09 to 0.05) | 0.545 |
| Tissue Doppler | ||||||
| Systolic velocity (s′), cm/s | 0.38 (−0.27 to 1.04) | 0.246 | 0.44 (−0.21 to 1.10) | 0.186 | 0.49 (−0.17 to 1.15) | 0.148 |
| Early diastolic velocity (e′), cm/s | −0.26 (−0.76 to 0.24) | 0.311 | −0.15 (−0.64 to 0.35) | 0.555 | 0.03 (−0.46 to 0.52) | 0.909 |
| Late diastolic velocity (a′), cm/s | 0.54 (−0.05 to 1.13) | 0.074 | 0.44 (−0.14 to 1.03) | 0.138 | 0.42 (−0.17 to 1.01) | 0.165 |
| Mean E/e′ ratio | 0.17 (−0.01 to 0.35) | 0.068 | 0.13 (−0.05 to 0.31) | 0.158 | 0.08 (−0.10 to 0.26) | 0.367 |
| Mean e′/a′ ratio | −0.06 (−0.11 to −0.02) | 0.005 | −0.05 (−0.09 to −0.01) | 0.025 | −0.03 (−0.08 to 0.01) | 0.110 |
Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, birth weight, body mass index (BMI), smoking, and socioeconomic status (SES). Model 3 adjusted for age, sex, birth weight, BMI, smoking, SES, and hypertension. BSA indicates body surface area; HDP, hypertensive disorders of pregnancy; LA, left atria; LV, left ventricular; O‐HDP, offspring of hypertensive disorders of pregnancy.