Table 2.
Significant Pathways (FDR <0.05) From the Metabolomics Pathway Analysis
| Pathway Name | Metabolitesa | Genesb | P Valuec | Q Valuec |
|---|---|---|---|---|
| Sphingolipid metabolism | 2 | 14 | 5.8E‐05 | 1.2E‐03 |
| Visual phototransduction | 2 | 26 | 1.4E‐04 | 1.2E‐03 |
| Phospholipases | 2 | 27 | 1.7E‐04 | 1.2E‐03 |
| Fatty acid alpha oxidation | 2 | 28 | 2.1E‐04 | 1.2E‐03 |
| Ceramide degradation | 2 | 28 | 3.3E‐04 | 1.5E‐03 |
| Triacylglycerol degradation | 2 | 29 | 9.2E‐04 | 3.5E‐03 |
| Sphingosine and sphingosine‐1‐phosphate metabolism | 2 | 10 | 1.6E‐03 | 5.5E‐03 |
FDR indicates false discovery rate.
a
Number of metabolites mapped to pathways, of the 13 significant metabolites associated with hydrochlorothiazide blood pressure response.
b
Number of genes identified within each pathway.
c
P values and q values were generated using the MPINet R‐based tool (http://cran.r-project.org/web/packages/MPINet/) based on Humancyc (https://humancyc.org/) as the pathways database source.