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. 2018 Jan 7;7(1):e007185. doi: 10.1161/JAHA.117.007185

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effect of tempol on blood pressure and sodium excretion in Sprague‐Dawley (SD) rats exposed to fine particulate matter (PM _2.5). SD rats exposed to PM _2.5 were treated with tempol for 3 weeks. Plasma superoxide dismutase (SOD) (A), glutathione peroxidase (GSH‐Px) (B), and malondialdehyde (MDA) (C) levels were checked in those rats (n=12 in each group). The blood pressure (D and E) and sodium excretion (F and G) were recorded (n=12 in each group). Moreover, the fenoldopam‐mediated urinary flow rate (H) and urine sodium excretion rate (I), G‐protein–coupled receptor kinase 4 (GRK4) expression (J), and dopamine D₁ receptor (D₁R) phosphorylations (K), as well as c‐Myc mRNA (L) and protein expressions (M) were checked (n=10 in each group). DBP indicates diastolic blood pressure; PM_2.5‐H, 30 μg PM _2.5 per time; and SBP, systolic blood pressure. *P<0.0001 vs control rats, ^# P<0.0001 vs PM _2.5‐H rats.