Table 3.

Differences of RyRs in the N-terminal and TM domains

		Animo acid position#
		114	129	151	188–189	240–247	4,452	4,504	4,647	4,758
Lepidoptera	GmRyR	L	Q	L	EV	TWSTEGGQ	D	P	V	I
	CsRyR	L	Q	L	EI	TWSKEGGQ	D	P	V	I
	SeRyR	L	Q	L	EV	TWTKDGGQ	D	P	V	I
	HvRyR	L	Q	L	EV	TWTKDGGQ	D	P	V	I
	HaRyR	L	Q	L	EV	TWTKDGGQ	D	P	V	I
	BmRyR	L	Q	L	EV	TWTRDGGQ	D	P	V	I
	OfRyR	L	Q	L	EV	AWAKETGQ	D	P	V	I
	CmRyR	L	Q	L	EV	TWTKDGGL	D	P	V	I
	PxRyR	L	Q	L	EV	SWSNEGQH	D	P	V	I
	PrRyR	L	Q	L	EV	TWNKDGGL	D	P	V	I
Coleoptera	LdRyR	Q	N	V	EI	TWDMEPGH	E	V	I	M
Homoptera	NlRyR	Q	N	V	DL	TWSEAPGQ	E	V	I	M
	SfRyR	Q	N	V	DL	TWSEAPGQ	E	V	I	M
	LsRyR	Q	N	V	DL	TWSEAPGQ	E	V	I	M
	BtRyR	Q	N	V	DL	NWTETTGQ	E	V	I	M
Diptera	AaRyR	N	N	V	DL	TWGQEPGQ	V	E	I	M
	DmRyR	H	N	V	EQ	TWGREAGQ	V	E	I	M
Nematode	TtRyR	V	T	I	MT	WSDHSQQN	S	V	V	L
	CeRyR	V	N	I	YM	NWSEHPQH	S	A	S	L
	SrRyR	V	S	I	DQ	WSENQIHN	K	I	I	L
Vertebrate	HsRyR1	A	T	M	GE	ADS-DDQR	R	T	G	C
	MmRyR1	A	T	M	GE	SDS-DDQR	R	T	G	C
	OcRyR1	A	T	M	GE	ADS-DDQR	R	T	G	C
	MgRyRα	S	T	L	GE	PEQGDERS	K	A	T	C
	RcRyRα	C	T	I	GD	TDQGEEQR	K	T	N	C
	HsRyR2	S	T	I	GS	GEHGEEQR	K	A	K	C
	MmRyR2	S	T	I	SS	GEHGEEQR	K	A	K	C
	OcRyR2	S	T	I	GS	GEHGEEQR	K	A	K	C
	HsRyR3	S	T	I	GN	TDQNDSQH	K	T	K	C
	MmRyR3	S	T	I	GS	TDQNDSQH	K	T	K	C
	OcRyR3	S	T	I	GN	TDQNDSQH	K	T	K	C
	MgRyRβ	S	T	I	GS	TDQGEEQR	K	T	K	C
	RcRyRβ	S	T	I	GN	TDQGEEQR	K	T	A	C

^#The number of amino acid M in the initial ORF from GmRyR represents 1.