. 2017 Nov 29;6(12):e005899. doi: 10.1161/JAHA.116.005899

Table 1.

Patient Demographic Data and Characteristics at Baseline Based on Type of Sleep‐Disordered Breathing

	OSA	OSA‐CSA	CSA
N (%)	452 (29)	624 (40)	481 (31)
Age, y	66±11^a	69±10	69±10^b
Female, n (%)	94 (21)^a	67 (11)	43 (9)^b
Body mass index, kg/m²	31±6^a	29±5^c	28±4^b
LVEF, %	35±8^a	34±8^c	32±8^b
NYHA class III+IV, n (%)	334 (74)^a	422 (68)^c	356 (74)
Ischemic cardiomyopathy, n (%)	226 (50)	343 (55)	279 (58)^b
Atrial fibrillation, n (%)	103 (23)^a	203 (33)	174 (36)^b
Medication, n (%)
ACE inhibitors and/or ARBs	394 (87)	572 (92)	431 (90)
β‐Blockers	391 (87)^a	571 (92)	436 (91)^b
Diuretics	349 (77)^a	519 (83)	398 (83)^b
Digitalis	64 (14)^a	126 (20)	101 (21)^b
Aldosterone antagonists	195 (43)	282 (45)	237 (49)
Polysomnography
AHI, per h	37±19	36±16	38±15^b
cAHI, per h	2±3^a	20±11^c	35±14^b
AI, per h	19±19^a	21±16	24±18^b
cAHI/AHI, %	6±6^a	54±17^c	92±6^b
Mean Sao ₂, %^d	92±3^a	93±2	93±3^b
Minimum Sao ₂, %^d	78±9^a	80±8^c	81±7^b
Time with Sao ₂<90%, min^e	62±78	51±69^c	50±70^b
Awake pco ₂, mm Hg	39±5^a	37±4^c	37±5^b

Values are mean±SD or number of patients (%). P‐values from ANOVA for metric variables and logistic regression for dichotomous variables; groupwise comparisons only in case of global significance (P<0.05). ACE indicates angiotensin‐converting enzyme; AHI, apnea‐hypopnea index; AI, apnea index; ARB, angiotensin receptor blocker; cAHI, central AHI; CSA, central sleep apnea (defined as cAHI/AHI ≥80.0%); LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; OSA, obstructive sleep apnea (defined as cAHI/AHI 0‐19.9%); OSA‐CSA, obstructive sleep apnea+central sleep apnea (defined as cAHI/AHI ≥20.0% and <80%); pco ₂, partial pressure of carbon dioxide; Sao ₂, oxygen saturation.

P<0.05 OSA vs OSA‐CSA.

P<0.05 CSA vs OSA.

P<0.05 OSA‐CSA vs CSA.

Values missing for 1 patient with OSA.

Values missing for 4 patients with OSA, 4 with OSA‐CSA, and 4 with CSA.