Table 1.
Electrocardiographic Parameters Derived From ECG Traces of Rat Groups
| Group | Heart Rate (bpm) | P Duration (ms) | PR Interval (ms) | QRS Duration (ms) | QT Interval (ms) | QTc Interval (ms) |
|---|---|---|---|---|---|---|
| Control | 290 (262–300) | 20.59 (19.60–22.08) | 55.05 (52.75–56.34) | 21.26 (20.62–22.47) | 68.77 (60.19–73.16) | 140.60 (132.10–158.40) |
| CHF+SE siRNA | 346 (321–368) | 24.91 (10.16–42.12) | 53.11 (47.24–58.75) | 24.53 (17.00–28.50) | 98.46 (92.35–109.60) | 232.62 (216.20–250.50) |
| CHF+SE | 328 (320–336)a | 18.17 (16.25–20.98) | 52.64 (51.56–54.14) | 21.57 (19.65–22.50) | 79.33 (73.07–88.46)a | 184.40 (177.50–188.30)a |
| CHF | 352 (315–383)b | 22.94 (12.16–35.38) | 55.85 (43.25–64.30) | 26.92 (19.18–30.92) | 89.01 (82.55–92.10)b | 205.10 (197.40–222.50)b |
| CHF+EGFP | 343 (340–376) | 23.98 (14.21–36.88) | 56.75 (53.62–60.75) | 23.50 (18.50–28.51) | 87.92 (80.28–98.14) | 203.74 (191.70–233.10) |
| CHF+AS | 372 (335–398)a | 31.11 (18.15–43.44) | 56.48 (48.62–61.80) | 24.50 (16.30–32.40) | 95.67 (89.51–106.80)a | 230.70 (218.20–237.00)a |
| CHF+AS siRNA | 331 (319–339)a | 26.53 (11.07–37.23) | 62.85 (53.82–62.60) | 19.50 (16.97–26.50) | 75.13 (69.68–82.13)a | 178.10 (165.40–187.80)a |
Data are given as median (25th–75th percentile). AS indicates antisense RNA; bpm, beats/min; CHF, congestive heart failure; EGFP, enhanced green fluorescent protein; QTc, corrected QT; and SE, sense, Kcna2.
a
Significant difference at P<0.05 when compared with the CHF group (n=10).
b
Significant difference at P<0.05 when compared with the control group (n=10).