Table 2.
Associations of Cardiac Parameters With WMFA: CARDIA Brain MRI Substudy
| Cardiac Parameter | Model 1 | Model 2 | ||
|---|---|---|---|---|
| ß (95% CI) | P Value | ß (95% CI) | P Value | |
| LVEF, per SD (n=297) | −0.0003 (−0.002 to 0.002) | 0.80 | 0.0001 (−0.002 to 0.002) | 0.94 |
| LAV, per SD (n=406) | −0.003 (−0.004 to −0.001) | 0.004a | −0.002 (−0.004 to −0.0004) | 0.016a |
| LV mass, per SD (n=627) | −0.002 (−0.003 to 0.0001) | 0.06 | −0.001 (−0.003 to 0.0003) | 0.11 |
Each cardiac parameter was transformed into a z score and entered into each model separately. ß is the coefficient for an association of the cardiac parameter (per SD) with the measure of aging brain. Model 1 is adjusted for age, sex, race/ethnicity, field center, years of education, and intracranial volume. Model 2 is adjusted for age, sex, race, field center, years of education, intracranial volume, systolic blood pressure, diastolic blood pressure, body mass index, total cholesterol, fasting plasma glucose, smoking status, sedentary time, alcohol intake, and APOE ɛ4 allele. CI indicates confidence interval; CARDIA, Coronary Artery Risk Development in Young Adults; LAV, left atrial volume; LV mass, left ventricular mass; LVEF, left ventricular ejection fraction; MRI, magnetic resonance imaging; WMFA, white matter fractional anisotropy.
Statistically significant at P<0.05.