Figure 3.

Results of the validation for candidate genes without correlation to AAA diameter. A, ADAMTS9, GFPT2, and STC1 were validated for higher expression levels in rAAA. B, Decreased gene expression for rAAA was also demonstrated for CCL4L1 and GAL3ST4 in the validation cohort, but their gene expression levels showed no significant correlation with diameter (rupture only–associated genes). Differential gene expression levels for SLC39A14 and RAB7B could not be reproduced. Gene expression levels were normalized to β‐actin. Data are illustrated as mean±SEM, and Mann‐Whitney U test was performed to identify differences in expression levels of selected genes between eAAA and rAAA. Spearman rank correlation coefficient (r) was determined to detect associations for gene expression levels and AAA diameter. AAA indicates abdominal aortic aneurysm; eAAA, elective AAA; rAAA, ruptured AAA.