Table 1.
Influence of IR, IPC, and IPoC on β‐AR–Mediated Effects 2 Hours After Myocardial Infarction
Heart Rate (beats/min) | ||
---|---|---|
Baseline | ISO | |
Nx | 244±44 | 318±26a |
IR | 234±42 | 305±48a |
IPC | 246±24 | 314±52a |
IPoC | 230±60 | 303±36a |
Perfusion Pressure (mm Hg) | ||
---|---|---|
Baseline | ISO | |
Nx | 57±8 | 46±3a |
IR | 64±8 | 55±7a |
IPC | 62±13 | 50±7a |
IPoC | 72±18 | 62±14a |
The heart rate increased and the perfusion pressure fell uniformly under ISO stimulation in all 4 treatment groups. A significant increase in the LVDP was observed only in hearts of the Nx, IR, and IPC groups. Data are means±SD of n=6 to 8 hearts.
IPC indicates ischemic preconditioning; IPoC, ischemic postconditioning; IR, ischemia/reperfusion; ISO, isoproterenol; LVDP, left ventricular developed pressure; Nx, normoxia.
P≤0.05 vs baseline.