Table 4.

Percent Change in Plaque Volume at 30‐Month Follow‐Up Compared to Baseline in the Control and Omega‐3 Ethyl‐Ester Groups for the Intention‐to‐Treat and Per‐Protocol Analyses

Plaque Volumea	Controls		Omega‐3 Ethyl‐Ester		% Change From Baseline
	Baseline Value Median [IQR]	30‐Month Value Median [IQR]	Baseline Value Median [IQR]	30‐Month Value Median [IQR]	Controls Median [IQR]	Omega‐3 Ethyl‐Ester Median [IQR]	P Valueb
Intention‐to‐treat
	(n=114)		(n=126)
Fatty	8.6 [5.1, 14.0]	8.6 [5.3, 13.7]	9.4 [4.9, 14.7]	9.3 [5.5, 14.8]	2.9 [−9.8, 15.1]	0.8 [−10.4, 20.1]	0.94
Fibrous	15.1 [8.7, 23.0]	15.9 [9.2, 23.5]	17.5 [9.5, 25.5]	16.1 [9.7, 24.3]	4.6 [−8.0, 18.5]	0.1 [−12.2, 14.9]	0.063
Noncalcified	23.7 [14.3, 36.8]	24.7 [14.5, 36.6]	26.4 [14.3, 39.7]	25.7 [15.0, 39.9]	4.5 [−6.1, 15.8]	−2.4 [−9.8, 16.7]	0.14
Calcified	3.6 [1.3, 7.3]	6.2 [2.6, 10.3]	5.0 [2.4, 8.7]	6.4 [3.3, 10.3]	57.4 [4.3, 146.6]	39.1 [−5.2, 118.1]	0.18
Total	28.1 [16.6, 44.3]	33.8 [18.1, 46.5]	33.2 [17.9, 47.0]	33.4 [19.1, 50.5]	10.0 [−3.1, 25.9]	6.5 [−6.9, 19.2]	0.11
Per‐protocol
	(n=97)		(n=122)
Fatty	9.6 [5.1, 14.1]	9.6 [5.3, 14.2]	9.7 [4.9, 15.0]	9.3 [5.5, 14.8]	0.2 [−8.9, 13.0]	0.4 [−10.6, 20.0]	0.99
Fibrous	16.0 [9.0, 23.5]	17.1 [9.3, 23.9]	17.7 [9.5, 25.7]	16.1 [9.7, 24.3]	5.0 [−5.7, 20.0]	−0.1 [−12.3, 14.5]	0.018
Noncalcified	26.9 [14.3, 37.2]	26.0 [14.9, 36.9]	27.1 [14.3, 40.0]	25.7 [15.0, 39.9]	4.4 [−5.9, 16.0]	−2.7 [−10.3, 16.4]	0.072
Calcified	3.7 [1.5, 7.6]	6.3 [3.0, 10.5]	5.1 [2.6, 8.7]	6.4 [3.7, 10.3]	59.2 [6.2, 154.1]	39.1 [−3.8, 121.4]	0.16
Total	30.9 [16.4, 45.7]	34.6 [18.6, 47.2]	33.9 [17.9, 47.4]	33.4 [19.3, 51.3]	9.9 [−3.3, 27.1]	6.3 [−7.4, 18.7]	0.087

^aPlaque volume expressed as mm³/mm.

^b P values calculated using a Mann–Whitney U test.

IQR indicates interquartile range.